原文

譯文

Prevalence and characteristics of psoriatic arthritis in Chinese patients with psoriasis

1.?????? Q Yang^1,2,?,

2.?????? L Qu^2,3,?,

3.?????? H Tian^2,3,

4.?????? Y Hu²,

5.?????? J Peng²,

6.?????? X Yu²,

7.?????? C Yu²,

8.?????? Z Pei²,

9.?????? G Wang²,

10.?? B Shi²,

11.?? F Zhang²,

12.?? Y Zhang⁴,

13.?? F Zhang^1,2,3

Article first published online: 23 FEB 2011

Arthritis & Rheumatism DOI:?10.1111/j.1468-3083.2011.03985.x

Abstract

?Background The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis vary widely in different countries and studies on Chinese population are rarely reported.

?Objective The aim of this study was to evaluate the prevalence and clinical characteristics of PsA in a Chinese population of patients with psoriasis.

?Methods A large cross-sectional observational study was conducted in our outpatient dermatology department and consecutive psoriatic patients were evaluated for PsA according to Classification of Psoriatic arthritis (CASPAR) criteria. Demographic and medical parameters were recorded.

?Results Among 1928 patients with psoriasis, 112 patients (5.8%) had PsA, of which 92% was newly diagnosed. Oligoarthritis (48.2%) was the most common manifestation pattern, followed by spondylitis (26.8%), polyarthritis (19.6%) and classic distal interphalangeal (DIP) arthritis (5.4%). Enthesitis was present in 26.8% and dactylitis in 13.4% of the patients. Compared with patients without PsA, patients with PsA had more severe skin disease (mean PASI 9.7 vs. 6.0), higher frequency of nail changes (46.4% vs. 21.0%) and scalp involvement (90.2% vs. 76.4%).

?Conclusion The findings are consistent with a low prevalence of PsA among patients with psoriasis in Asia and confirm a high percentage of undiagnosed cases with active arthritis among PsA patients in dermatologist’s office. Dermatologists should screen for PsA in their patients, especially those with risk characteristics and early signs.

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中國銀屑病患者中銀屑病關節炎的患病率和特征

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背景 銀屑病患者中銀屑病關節炎(PsA)的患病率和臨床特點在不同的國家有很大的差異, 而中國人群的研究鮮有報道。

目的 本研究旨在評估中國銀屑病患者中PsA的患病率和臨床特點。

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方法 對我們皮膚科門診連續的銀屑病患者進行大型橫貫面觀察研究，按照銀屑病關節炎（CASPAR）分類標準評價是否存在PsA。并記錄人口學和臨床參數。

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結果1928例銀屑病患者中，112例(5.8%)患者有銀屑病關節炎，其中92%是新診斷的。寡關節炎（48.2%）是最常見的表現模式,其次是脊柱關節炎(26.8%),多關節炎(19.6%)和典型的遠端指間(DIP)關節炎(5.4%)。附著點炎和趾炎的發生率分別為26.8%和13.4%。與沒有PsA的患者相比， PsA患者皮膚疾病的嚴重程度 (平均PASI 9.7 vs. 6.0)、指甲改變(46.4% vs.21%)和頭皮累及（90.2%vs. 76.4%）的比例都更高。

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結論 以上結果與亞洲銀屑病患者中PsA患病率低相一致，并證實了皮膚病診室中有活動性關節炎的PsA患者漏診率較高。皮膚科醫師應當對有高危因素和早期癥狀的銀屑病患者是否存在PsA進行篩查。

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