首先，在對Excel文件進行操作時，首先應該注意引用（word為一起加的，這里為非必要）

using MSWord = Microsoft.Office.Interop.Word; using MSExcel = Microsoft.Office.Interop.Excel;

（1）、能打開指定的Excel文件

private void button1_Click(object sender, EventArgs e){Form2 myform = new Form2();myform.ShowDialog();MessageBox.Show("hello world");OpenExcel(@"D:\工作簿2.xls");} （2 ）、定義一個方法打開文件（主要是初始化）

static void OpenExcel(string filename)//定義方法OpenExcel{MSExcel.Application excelApp = null;excelApp = new MSExcel.Application();excelApp.Visible = true;excelApp.DisplayAlerts = false;//保存Excel的時候，不彈出是否保存的窗口直接進行保存excelApp.AlertBeforeOverwriting = false;MSExcel.Workbook excelbook = null;MSExcel.Worksheet excelsheet = null;excelbook = excelApp.Workbooks.Open(filename, Type.Missing,false, Type.Missing, Type.Missing, Type.Missing, Type.Missing,Type.Missing, Type.Missing, Type.Missing, Type.Missing,Type.Missing, Type.Missing, Type.Missing, Type.Missing);//表1excelsheet = excelbook.Sheets["hello1"] as MSExcel.Worksheet;string str1 = excelsheet.Cells[1, 1].Text.ToString();string str2 = excelsheet.Cells[1, 2].Text.ToString();MSExcel.Range rang1 = excelsheet.get_Range("E3:F5");string str3 = rang1.Cells[1, 1].Text.ToString();string str4 = rang1.Cells[1, 2].Text.ToString();excelsheet.Cells[5, 1] = "yoyou";excelsheet.Cells[8, 4] = "yoyo12u";excelbook.Save();excelbook.Close();excelApp.Quit();//逐級關閉，不可省略} 其中：

MSExcel.Application excelApp = null;excelApp = new MSExcel.Application();//打開Excel程序，使之運行excelApp.Visible = true;excelApp.DisplayAlerts = false;//保存Excel的時候，不彈出是否保存的窗口直接進行保存excelApp.AlertBeforeOverwriting = false; 為初始化操作。

尤其注意最后逐級關閉打開的系統，即為最后三行。

完整如下：

using System; using System.Collections.Generic; using System.ComponentModel; using System.Data; using System.Drawing; using System.Linq; using System.Text; using System.Windows.Forms; using MSWord = Microsoft.Office.Interop.Word; using MSExcel = Microsoft.Office.Interop.Excel;namespace MyTest1 {public partial class Form1 : Form{public Form1(){InitializeComponent();}static void OpenExcel(string filename){MSExcel.Application excelApp = null;excelApp = new MSExcel.Application();excelApp.Visible = true;excelApp.DisplayAlerts = false;//保存Excel的時候，不彈出是否保存的窗口直接進行保存excelApp.AlertBeforeOverwriting = false;MSExcel.Workbook excelbook = null;MSExcel.Worksheet excelsheet = null;excelbook = excelApp.Workbooks.Open(filename, Type.Missing,false, Type.Missing, Type.Missing, Type.Missing, Type.Missing,Type.Missing, Type.Missing, Type.Missing, Type.Missing,Type.Missing, Type.Missing, Type.Missing, Type.Missing);//表1excelsheet = excelbook.Sheets["hello1"] as MSExcel.Worksheet;string str1 = excelsheet.Cells[1, 1].Text.ToString();string str2 = excelsheet.Cells[1, 2].Text.ToString();MSExcel.Range rang1 = excelsheet.get_Range("E3:F5");string str3 = rang1.Cells[1, 1].Text.ToString();string str4 = rang1.Cells[1, 2].Text.ToString();excelsheet.Cells[5, 1] = "yoyou";excelsheet.Cells[8, 4] = "yoyo12u";excelbook.Save();excelbook.Close();excelApp.Quit();}private void button1_Click(object sender, EventArgs e){Form2 myform = new Form2();myform.ShowDialog();MessageBox.Show("hello world");OpenExcel(@"D:\工作簿2.xls");}} }

總結

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